(Previously Boath House) and Meedu Saad (Super8 Restaurants).
Other awards saw Jason Atherton and wife Irha of The Social Company were crowned Restaurateur of the Year, while Timberyard & Montrose in Edinburgh won the Drinks List of the Year prize.
Edinburgh was named the Most Exciting Food Destination for 2025, with Lloyd Morse and James Snowdon of The Palmerston accepting the award on behind of the Scottish capital.
Andrew Lloyd-Webber welcomed guests at the start of the night to his theatre, before TV presenter Richard Bacon hosted the awards.
Chloë Hamilton, editor of The Good Food Guide, explaining Osip’s Restaurant of the Year win, said: “More so now than ever, Merlin’s cooking offers a sense of place that leaps off the plate with a stunning clarity of flavour.
“Our decision was down to the wire but the latest of our multiple (anonymous) visits to Osip’s new home in January was a showcase of style and confidence; totally aspirational but without unnecessary frills or a huge price tag.”
The Good Food Guide was first compiled by Raymond Postgate in 1951.